Aniso - a dirty drug?

The say long-term learning depends on protein synthesis.  A recent J Neurosci article from Sharma et al. suggests, however, that the most common protein synthesis inhibitor (anisomycin) also blocks neural activity, greatly complicating the intepretation of studies using this drug.  This had me running to the lab to check if the finding applies to Aplysia as well (I happened to be in the midst of an experiment using it!).  Happy to say, that consistent with several reports from the Kandel lab (and others), Aniso did *not* decrease spontaneous activity in the nerves of the abdominal ganglion when applied at 10 and 20um.  So what gives?  Is it a vertebrate only effect or is something else going on?

Sharma, a. V., Nargang, F. E., & Dickson, C. T. (2012). Neurosilence: Profound Suppression of Neural Activity following Intracerebral Administration of the Protein Synthesis Inhibitor Anisomycin. Journal of Neuroscience, 32(7), 2377-2387. doi:10.1523/JNEUROSCI.3543-11.2012.  http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3543-11.2012